Probably suffer a bunch of bugs and optimisation issues, other than that I would try to explore before deciding on a path I want to follow when it comes to choosing career choice.

I think there will be a similar system to the Asylum Arma server, where you suffer from withdrawals if you become addicted to drugs. When it comes to sickness, I do not think it will be anything major, more like you getting a notification saying you are sick and that you need to visit a hospital vendor and heal up, otherwise you would slowly perish. This could be very interesting, seeing as a wanted criminal would not want to visit a populated area.